Grant Hennig

Grant Hennig

Contact Information
Office Location:
Department of Pharmacology, 89 Beaumont Ave., Burlington, VT 05405


1999  Ph.D. Neurobiology, Flinders University, Adelaide, South Australia

1993  B.Sc (Hon) Neurobiology, Flinders University, Adelaide, South Australia

1992  B.Sc. Physiology/Pharmacology, Adelaide University, South Australia

Professional Positions

2016  Assistant Professor, Department of Pharmacology, University of Vermont

2008-2016  Assistant Professor, (tenured in 2013), Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, NV

2004-2008  Research Assistant Professor, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV

2002-2004  Postdoctoral Fellow, Department of Human Physiology, Flinders University, South Australia

1992-2002  Postdoctoral Fellow, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV

Research Interests

1)  Pattern analysis of activity in excitable cell networks (e.g. Interstitial cells of Cajal, enteric neurons) using Ca2+ imaging.

2)  Modification of gastrointestinal motor patterns in health and disease (gastroparesis in Type 2 diabetes) using remote imaging (video, ultrasound, infrared).

3)  Multi-dimensional imaging analysis software for structural and motion analysis.

4)  DNA/RNA sequence analysis and visualization software.

Awards and Honors

2001  Servier Distinguished Young Investigator Award

2000-2004  CJ Martin Postdoctoral Fellowship (NH&MRC Australia)

1994-1997  Gastroenterology Society of Australia Biomedical Research Scholarship


For a complete list of publications go to PubMed.

2021 Longden TA, Mughal A, Hennig GW, Harraz OF, Shui B, Lee FK, Lee JC, Reining S, Kotlikoff MI, Konig GM, Kostenis E, Hill-Eubanks D, Nelson MT.  Local IP3 receptor-mediated Ca2+ signals compound to direct blood flow in brain capillaries.  Sci Adv.  2021 Jul 21; 7(30):  eabh0101.  doi:  10.1126/sciadv.abh0101.  PMID:  34290098, PMCID:  PMC8294755

2021 Yuan S, Wang Z, Peng H, Ward SM, Hennig GW, Zheng H, Yan W.  Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport.  Proc Natl Acad Sci USA.  2021 Jun 1; 118(22):  22102940118.  doi:  10.1073/pnas.2102940118.  PMID:  34039711, PMCID:  PMC8179221

2020 Konen JR, Haag MM, Guseva D, Hurd M, Linton AA, Lavoie B, Kerrigan CB, Joyce E, Bischoff SC, Swann S, Griffin L, Matsukawa J, Falk MD, Gibson TS, Hennig GW, Wykosky J, Mawe GM. Prokinetic actions of luminally acting 5-HT4 receptor agonists.  Neurogastroenterol Motil.  2021 Apr; 33(4):  e1026.  doi:  10.1111/nmo.14026.  PMID:  33185015, PMCID:  PMC7990683

2020 Coleman JR, Moore EE, Freeman K, Grubinger ND, Hennig GW, Cohen MJ, Samuels JM, Hansen K.  Actin is associated with tissue injury in trauma patients and produces a hypercoagulable provile in vitro.  J Trauma Acute Care Surg.  2020 Jul; 89(1): 87-95.  doi: 10.1097/TA0000000000002739.  PMID:  32574484

2020 Dow N, Coleman JR, Moore H, Osborn ZT, Sackheim AM, Hennig G, Butenas S, Nelson MT, Moore EE, Freeman F.  Dense and dangerous:  The tissue plasminogen activator-resistant fibrinolysis shutdown phenotype is due to abnormal fibrin polymerization.  J Trauma Acute Care Surg.  2020 Feb; 88(2):  258-265.  doi:  10.1097/TA.0000000000002554.  PMID:  41999655, PMCID:  PMC7546039

2019 Girard BM, Campbell SE, Perkins M, Hsiang H, Tooke K, Drescher C, Hennig GW, Heppner TJ, Nelson MT, Vizzard MA.  TRPV4 blockade reduces voiding frequency, ATP release, and pelvic sensitivity in mice with chronic urothelial overexpression of NGF.  Am J Physiol Renal Physiol.  2019 Dec 1; 317(6):  F1695-F1706.  doi:  10.1152/ajprenal.00147.2019.  PMID:  31630542, PMCID:  PMC6962511

2019 Thorsdottir D, Cruickshank NC, Einwag Z, Hennig GW, Erdos E.  BDNF downregulates ß-adrenergic receptor mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus. Am J Physiol Heart Circ Physiol. 2019 Dec 1; 317(6): H1258-H1271.  doi: 10.1152/ajpheart.00478.2019.  PMID:  31603352, PMCID:  PMC6962618

2019 Hwang SJ, Pardo DM, Zheng H, Bayguinov Y, Blair PJ, Fortune-Grant R, Cook RS, Hennig GW, Shonnard MC, Grainger N, Peri LE, Verma SD, Rock J, Sanders KM, Ward SM. Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility. J Physiol.  2019 May; 597(9):  2337-2360.  doi:  10.1113/JP277335.  PMID:  30843201, PMCID:  PMC6487927

2019 Drumm BT, Hennig GW, Baker SA, Sanders KM.  Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ signaling in Situ.  J Vis Exp.  2019 Jan 7; (143): 103791/58989.  doi:  10.3791/58989.  PMID:  30663707, PMCID:  PMC6996781

2019 Yuan S, Liu Y, Peng H, Tang C, Hennig GW, Wang Z, Wang L, Yu T, Klukovich R, Zhang Y Zheng H, Xu C. Wu J, Hess RA, Yan W.  Motile cilia of the mail reproductive system require miR-34/miR-449 for development and function to generate luminal turbulence.  Proc Natl Acad Sci USA.  2019 Feb 26; 116(9):  3584-3493.  doi:  10.1073/pnas.1817018116.  PMID:  30659149, PMCID:  PMC6397547

2019 Heppner TJ, Hennig GW, Nelson MT, May V, Vizzard MA.  PACAP38-Mediated Bladder Afferent Nerve Activity Hyperexcitability and Ca2+ Activity in Urothelial Cells from Mice. J Mol Neurosci.  2019 Jul; 68(3):  348-356. doi:  10.1007/s12031-018-1119-x.  PMID:  30022438, PMCID:  PMC6339595