2002 B.S., Science and Technologies Studies, Lyman Briggs College, Michigan State University
2012 Ph.D., Pharmacology and Toxicology, Michigan State University, Advisors: Dr. Stephanie Watts and Dr. Bill Jackson
2015 Research Assistant Professor, Pharmacology, University of Vermont
2012 - 2015 Postdoctoral Associate, Nelson Lab, University of Vermont
2007 Research Assistant for Dr. Stephanie Watts, Michigan State University
2005 American Red Cross Donor Recruitment Representative
2004-2005 Admissions Advisor, Baker College of Owosso
2002-2004 Professional Sales Representative, Altana Pharma, Inc.
NIDDK KO1 DK103840 Mentored Research Scientist Development Award. 07/01/15-06/30/20
This project investigates how alterations in urinary bladder blood flow and vascular contractility affect bladder function, both normally and in diabetes. PI: Nathan Tykocki
2014 Best Postdoctoral Presentation, 15th Annual Pharmacology Research Retreat, Nov. 13-14, 2014
2011 Award: Third Place in Oral Presentations, 38th Annual Pharmacology Research Colloquium
2009 Scholarship: Keystone Symposium - Dissecting the Vasculature: Function, Molecular Mechanisms, and Malfunction
2008 Session Moderator: 35th Annual Pharmacology Research Colloquium.
Recipient: Michigan State University Graduate School Summer Research Fellowship
2007 Travel Award: 6th Hypertension Summer School
2014, 2015, 2016, 2017 Lecturer, Topics in Molecular and Cellular Pharmacology, PHRM 290: IP3 Receptors section, University of Vermont
2016 Lecturer, Human Physiology & Pharmacology MPBP 301: Voltage-dependent Ion Channels, Smooth Muscle E-C Coupling Autonomic Nervous System: Structure & Function
2011 Lecturer, Introduction to Chemical Toxicology PHM 450: renal and cardiovascular toxicology sections, Michigan State University
2011 Teaching Assistant for Experimental Design and Analysis, PHM 830, Michigan State University
2010 Tutor for Introduction to Pharmacology (PHM 350), Michigan State University
2009 Teaching Assistant for Pharmacokinetics and Pharmacodynamics (PHM 819), Michigan State University
2001-2002 Teaching Assistant for Chemistry Laboratory (LSB 171 & 72) Lyman Briggs School, Michigan State University
For a complete listing of Nathan Tykocki's publications, please visit PubMed.
2017 Tykocki NR, Boerman EM, Jackson WF. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles. Compr Physiol. 2017 Mar 16; 7(2): 485-581. doi: 10.1002/cphy.c160011. PMID: 28333380
2017 Longden TA, Dabertrand F, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT. Capillary K+ sensing initiates retrograde hyperpolarization to increase local cerebral blood flow. Nat Neurosci. 2017 May; 20(5): 717-726. doi: 10.1038/nn.4533. PMID: 28319610, PMCID: 5404963
2017 Tykocki NR, Bonev AD, Longden TA, Heppner TJ, Nelson MT. Inhibition of vascular smooth muscle inward-rectifier K+ channels restores myogenic tone in mouse urinary bladder arterioles. Am J Physiol Renal Physiol. 2017 May 1; 312(5): F836-F847. doi: 10.1152/ajprenal.00682. PMID: 28148533, PMCID: PMC5451557
2016 Heppner TJ, Tykocki NR, Hill-Eubanks D, Nelson MT. Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling. J Gen Physiol. 2016 Apr; 147(4): 323-335. doi: 10.1085/jgp.201511550. PMID: 26976828, PMCID: PMC4810069
2015 Moon TM, Tykocki NR, Sheehe JL, Osborne BW, Tegge W, Brayden JE, Dostman WR, Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinases 1a. Chem Biol. 2015 Dec 17; 22(12): 1653-1661. doi: 10.1016/j.chembiol.2015.11.005. PMID: 26687482, PMCID: PMC4703045
2015 Tykocki NR, Nelson MT. Location, Location, Location: Juxtaposed calcium-signaling microdomains as a novel model of the vascular smooth muscle myogenic response. J Gen Physiol. 2015 Aug; 146(2): 129-132. doi: 10.1085/jgp.201511468. PMID: 26216858, PMCID: PMC4516781
2015 Mingin GC, Heppner TJ, Tykocki NR, Erickson CS, Vizzard MA, Nelson MT. Social stress in mice induces urinary bladder overactivity and increases TRPV1 channel-dependent afferent nerve activity. Am J Physiol Regul Integr Comp. 2015 Sep 15; 309(6): R629-R638. doi: 10.1152/ajpregu.00013.2015. PMID: 26224686, PMCID: PMC4591369
2015 Jespersen B, Tykocki NR, Watts SW, Cobbett PJ. Measurement of smooth muscle function in the isolated tissue bath-applications to pharmacology research. J Vis Exp. doi: 10.3791/52324. PMID: 25650585, PMCID: PMC4354551
2015 Petersen-Jones HG, Johnson KB, Hitomi K, Tykocki NR, Thompson JM, Watts SW. Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls. Am J Physiol Heart Circ Physiol. doi: 10.1152/ajpheart.00402.2014. PMID: 25599570, PMCID: PMC 4360056
2014 Tykocki NR, Wu B, Jackson WF, Watts SW. Divergent signaling mechanisms for venous versus arterial contraction as revealed by endothelin-1. J Vasc Surg. doi: 10.1016/jvs.2014. PMID: 24726828, PMCID: PMC4193972
2013 Davis RP, Szasz T, Garver H, Burnett R, Tykocki NR, Watts SW. One-month serotonin infusion results in a prolonged fall in blood pressure in the deoxycorticosterone acetate (DOCA) salt hypertensive rat. ACS Chem Neurosci. doi: 10.1021/cn300114a. PMID: 23336053, PMCID: PMC3547487
2012 Tykocki NR, Jackson WF, Watts SW. Reverse-mode Na+/Ca2+ exchange is an important mediator of venous contraction. Pharmacol Res. doi: 10.1016/jphrs.2012.08.004. PMID: 22974823, PMCID: PMC3502721
2010 Tykocki NR, Watts SW. The interdependence of endothelin-1 and calcium: a review. Clin Sci. doi: 10.1042/CS20100145. PMID: 20662769, PMCID: PMC3960801
2009 Tykocki NR, Gariepy CE, Watts SW. Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein. J Pharmacol Exp Ther. doi: 10.1124/jpet.108.145953. PMID: 19297422, PMCID: PMC2683769