Dr. Morrical received his Ph.D. in Biochemistry from the University of Wisconsin-Madison in 1987. His postdoctoral research at the University of California-San Francisco focused on mechanisms of recombination-dependent DNA synthesis and repair. He joined the UVM Biochemistry faculty in 1992. Dr. Morrical is also an adjunct member of the MMG department and a member of the Vermont Cancer Center. His research is funded by grants from the NIH and National Cancer Institute.
All Morrical Publications
Chen J, Morrical MD, Donigan KA, Weidhaas JB, Sweasy JB, Averill AM, Tomczak JA, Morrical SW. (2015). Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase. Nucleic Acids Res. PubMed PMID: 25539919
Branagan AM, Klein JA, Jordan CS, Morrical SW. (2014). Control of helicase loading in the coupled DNA replication and recombination systems of bacteriophage T4. J Biol Chem. 289:3040-54. PubMed PMID: 24338568; PubMed Central PMCID: PMC3908434.
Liu J, Berger CL, Morrical SW. (2013). Kinetics of presynaptic filament assembly in the presence of single-stranded DNA binding protein and recombination mediator protein. Biochemistry 52:7878-89. PubMed PMID: 24124995; PubMed Central PMCID: PMC3864638.
Maher RL, Morrical SW. (2013). Coordinated Binding of Single-Stranded and Double-Stranded DNA by UvsX Recombinase. PLoS One 8:e66654. PubMed PMID: 23824136; PubMed Central PMCID: PMC3688935.
Branagan AM, Maher RL, Morrical SW. (2012). Assembly and dynamics of Gp59-Gp32-single-stranded DNA (ssDNA), a DNA helicase loading complex required for recombination-dependent replication in bacteriophage T4. J Biol Chem. 287:19070-81. PubMed PMID: 22500043; PubMed Central PMCID: PMC3365940.
Maher RL, Branagan AM, Morrical SW. (2011). Coordination of DNA replication and recombination activities in the maintenance of genome stability. J Cell Biochem. 112:2672-82. PubMed PMID: 21647941; PubMed Central PMCID: PMC3178728.
Liu J, Ehmsen KT, Heyer WD, Morrical SW. (2011). Presynaptic filament dynamics in homologous recombination and DNA repair. Crit Rev Biochem Mol Biol. 46:240-70. PubMed PMID: 21599536; PubMed Central PMCID: PMC4083101.
Chen J, Villanueva N, Rould MA, Morrical SW. (2010). Insights into the mechanism of Rad51 recombinase from the structure and properties of a filament interface mutant. Nucleic Acids Res. 38:4889-906. PubMed PMID: 20371520; PubMed Central PMCID: PMC2919713.
Xu H, Beernink HT, Morrical SW. (2010). DNA-binding properties of T4 UvsY recombination mediator protein: polynucleotide wrapping promotes high-affinity binding to single-stranded DNA. Nucleic Acids Res. 38:4821-33. PubMed PMID: 20371513; PubMed Central PMCID: PMC2919719.