2004-2006 Ph.D. Neuroscience and Neuropharmacology, University of Bordeaux, Bordeaux, France
2003-2004 Master Research, Neuroscience and Neuropharmacology, University of Bordeaux, Bordeaux, France
2002-2003 B.S. Cell Biology and Physiology, University of Bordeaux, Bordeaux, France
2001-2002 B.S. Structural Biochemistry, University of Bordeaux, Bordeaux, France
2000-2001 Licence (3 Year Degree) Biochemistry, University of Bordeaux, Bordeaux, France
1999-2000 Diploma of General University Studies, University of Bordeaux, Bordeaux, France
2014 - present Research Assistant Professor, University of Vermont, Dept. of Pharmacology
2009 - 2013 Postdoctoral Fellow, University of Vermont, Dept. of Pharmacology
2007-2008 Postdoctoral Fellow, University of Bordeaux, Centre for Cognitive and Integrative Neurosciences -CNRS UMR 5228
2012 - present Lecturer, PHRM 290, Topics in Molecular and Cellular Pharmacology - Topic: "Ryanodine Receptors", University of Vermont
2014 Lecturer, MPBP 310, Topics in Molecular Control of the Cell - Topic: "Global and Local Calcium Signaling", University of Vermont
2008 - Lecturer to 4th year Pharmacy Students, Topic: "Calcium Signaling in Smooth Muscle Cells", University of Bordeaux
2008 - Lecturer to 3rd year Pharmacy Students - Topics - "Calcium Signaling in Cardiac Myocytes" and "Special Topic - Confocal Microscopy", University of Bordeaux
2007 Lecturer to 3rd year Pharmacy Students - Topics: "Calcium Signaling in Cardiac Myocytes" and "Special Topic - Photonic Microscopy and initiation to the Fluorescence Microscope", University of Bordeaux
National Institutes of Health 1R01 HL136636/1-5 "Capillary control of cerebral blood flow, and its disruption in small vessel disease", PI F. Dabertrand, 2/1/17-1/31/22
Fondation Leducq 12/2012 - 12/2017 Transatlantic Network of Excellence on the Pathogenesis of Small Vessel Disease of the Brain. Mark T. Nelson, Ph.D., (North American Coordinator) and Anne Joutel, M.D., Ph.D., (European Coordinator)
American Heart Association 07/2009 - 06/2011, Postdoctoral Fellowship, PI, Joseph E. Brayden, Ph.D., Co-sponsor, Mark T. Nelson, Ph.D.
French Space Agency (CNES) 12/2006 - 11/2008, PI, J.L. Morel
2015 New Investigator Award, American Physiological Society, Cardiovascular Section
2013 Durwood J. Smith Prize - Best Postdoctoral Poster, Annual Pharmacology Research Retreat
"Profound decrease in myogenic tone of parenchymal arterioles in a genetic model of cerebral ischemic small vessel disease", Dabertrand F, Bonev AD, Ingalls JE, Brayden JE, Joutel A, Nelson MT
2010 Durwood J. Smith Prize, Best Postdoctoral Oral Presentation, Annual Pharmacology Retreat
"Role of ryanodine receptor in acidic pH-induced dilation of parenchymal arterioles", Dabertrand F, Nelson MT, Brayden JE
2008 2nd Place Young Researcher Poster Award at Life in Space for Life on Earth Symposium, conjointly organized by ESA, ISGP, ASGSB and ELGRA
"Modification of Calcium Signaling in Cerebral Myocytes by Simulated Microgravity", Dabertrand F & Morel JL
2007 Article Recommendation in Faculty of 1000 Biology database by Pr. Antony Galione, University of Oxford
"Role of RYR3 Splice Variants in Calcium Signaling in Mouse Nonpregnant and Pregnant Myometrium", Dabertrand F et al., American Journal of Physiology, Cell Physiology
For a complete list of Fabrice Dabertrand's publications, visit PubMed
2017 Longden TA*, Dabertrand F*, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT. Capillary K+ sensing initiates retrograde hyperpolarization to increase local cerebral blood flow. Nat Neurosci. 2017 May; 20(5): 717-726. doi: 10.1038/nn.4533. PMID: 28319610, PMCID: PMC4504963 *Equal contribution
2016 Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A. Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics. Elife. 2016 Aug 1; 5. pii: e17536. doi: 10.7554/eLife.17536. PMID: 27476853, PMCID: PMC4993587
2016 Pires PW, Dabertrand F, Earley S. Isolation and Cannulation of Cerebral Parenchymal Arterioles. J Vis Exp. 2016 May 23; (111). doi: 10.3791/53835. PMID: 27286481
2015 Dabertrand F, Kroigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT. Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1420765112. PMID: 25646445, PMCID: PMC4343103
2015 Boursereau R, Donadieu A. Dabertrand F, Dubayle D, Morel JL. Blood brain barrier precludes the cerebral arteries to intravenously-injected antisense oligonucleotide. Eur J Pharmacol. doi: 10.1016/j.ejphar.2014. PMID: 25510229
2014 Gonzales AL, Yang Y, Sullivan MN, Sanders L, Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S. A PLCy1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries. Sci Signal. doi: 10.1126/scisignal.2004732. PMID: 24866019, PMCID: PMC4170587
2014 Longden TA, Dabertrand F, Hill-Eubanks DC, Hammack SE, Nelson MT. Stress-induced glucocordicoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1401811111. PMID: 24808139, PMCID: PMC4034203
2013 Morel JL*, Dabertrand F*, Porte Y, Prevot A, Macrez N. Up-regulation of ryanodine receptor expression increases the calcium induced calcium release and spontaneous calcium signals in cerebral arteries from hindlimb unloaded rats. Pflugers Arch. doi: 10.1007/s00424-13-1387-9. PMID 24233561 *Equal contribution
2013 Dabertrand F, Hannah RM, Pearson JM, Hill-Eubanks DC, Brayden JE, Nelson MT. Prostaglandin E2, a postulated astrocyte-derived coupling agent, constricts rather than dilates parenchymal arterioles. J Cereb Blood Flow Metab. doi: 10.1038/jcbfm.2013.9. PMID: 23385200, PMCID: PMC3618402
2013 Dabertrand F, Nelson MT, Brayden JE. Ryanodine receptors, calcium signaling and regulation of vascular tone in the cerebral parenchymal microcirculation. Micocirculation Invited Review. doi: 10.1111/micc.12027. PMID: 23216877, PMCID: PMC3612564
2012 Dabertrand F, Porte Y, Macrez N, Morel JL. Spaceflight regulates ryanodine receptor subtype 1 in portal vein myocytes in the opposite way of hypertension. J Appl Physiol. doi: 10.1152/japplphysiol.00733.2011. PMID: 22096120
2012 Dabertrand F, Nelson MT, Brayden JE. Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels. Circ Res. doi: 10.1161/CIRCRESAHA.111.258145. PMID: 22095728, PMCID: PMC350882
2010 Dabertrand F, Mironneau J, Henaff M, Macrez N, Morel JL. Comparison between gentamycin and exon skipping treatments to restore ryanodine receptor subtype 2 functions in mdx mouse duodenum myocytes. Eur J Pharmacol. doi: 10.1016/j.ejphar.2009.11.034. PMID: 19944091
2009 Morel JL, Dabertrand F, Fritz N, Henaff M, Mironneau J, Macrez N. The decrease of expression of ryanodine receptor subtype 2 is reversed by gentamycin sulfate in vascular myocytes from mdz mouse. J Cell Mol Med. doi: 10.1111/j.1582-4934.2009.00718.x. PMID: 19298530
2008 Fritz N, Dabertrand F, Mironneau J, Macrez N, Morel JL. Acetylcholine evokes an InsP3R1-dependent transient Ca 2+ signal in rat duodenum myocytes. Can J Physiol Pharmacol. 2008 Sep; 86(9): 626-632. PMID: 18758512
2008 Dabertrand F, Mironneau J, Macrez N, Morel JL. Full length ryanodine receptor type 3 encodes spontaneous calcium oscillations in native duodenal smooth muscle cells. Cell Calcium. doi: 10.1016/j.ceca.2007.11.009. PMID 18207571
Chapters
2008 Morel JL, Dabertrand F. "Vascular tone adaptation to gravity changes by calcium signaling." Space Science Research in France, pp84-85, Ed COSPAR.
Morel JL, Fritz N, Dabertrand F, Macrez N. "Ca2+ releasing channels of smooth muscle sarcoplasmic reticulum. Special Review Book - New Frontiers in Smooth Muscle Biology and Physiology, pp 131-150 (Editor: Jean-Pierre Savineau).