1978-1980 Penn State University, University Park, PA --June 1978-August 1979, June 1980-August 1980
1981 B.S. in Science with highest distinction, Penn State University
1979-1983 Jefferson Medical College, Philadelphia, PA
1983 M.D. Jefferson Medical College
1992-1995 Postdoctoral Biotechnology Fellow
Laboratory of Human Carcinogenesis
Curtis C. Harris, M.D., Chief
National Cancer Institute, NIH, Bethesda, MD
1988-1991 Fellow, Division of Hematology/Oncology
University of New Mexico Affiliated Hospitals Albuquerque, NM
1987 Chief Resident, Internal MedicineUniversity of New Mexico Affiliated Hospitals Albuquerque, NM
1983-1986 Intern and Resident, Internal Medicine
University of New Mexico Affiliated Hospitals Albuquerque, NM
1991, 2001, 2011 American Board of Internal Medicine Subspecialty in Medical Oncology
1986 American Board of Internal Medicine
1984 National Board of Medical Examiners
Gastrointestinal Cancers
Cancer Genetics (Familial Cancer Program)
Dr. Greenblatt's research interests are in interpreting genetic variants in cancer susceptibility genes by using multiple lines of evidence (epidemiology, statistics, tumor pathology, evolution, structure, and function, computational algorithms). He has led projects that have integrated in vitro and in silico (computational) data to interpret genetic variation. Dr. Greenblatt’s current research activities involve interpretation of variants in the DNA mismatch Repair genes that are responsible for Lynch syndrome, the most common form of hereditary colorectal cancer.
Human Genome Variation Society, President 2012
American Association of Cancer Research
Alliance for Clinical Trials in Oncology
American Society of Human Genetics
American Society of Clinical Oncology
Collaborative Group of the Americas on Inherited Colorectal Cancer
Human Variome Project, Scientific Advisory Council
International Society for Gastrointestinal Hereditary Tumors (InSiGHT), Variant Interpretation Committee
Vermont Medical Society
For a complete list of Marc Greenblatt's publications, please visit Google Scholar.
Drost M, Tiersma Y, Thompson BA, Frederiksen JH, Keijzers G, Glubb D, Kathe S, Osinga J, Westers H, Pappas L, Boucher KM, Molenkamp S, Zonneveld JB, van Asperen CJ, Goldgar DE, Wallace SS, Sijmons RH, Spurdle AB, Rasmussen LJ, Greenblatt MS, de Wind N, Tavtigian SV, A Functional Assay-Based Procedure to Classify Mismatch Repair Gene Variants in Lynch Syndrome, Genet Med, 2019, 21(7):1486-1496, PMID: 30504929
Seifert BA, Jackson SA, McGlaughon J, Ritter DI, Roberts ME, Schmidt RJ, Thompson BA, Jimenez S, Trapp M, Lee K, Plon SE, Offit K, Berg JS, Stadler ZK, Zhang L, Greenblatt MS, Ferber MJ, Determining the clinical validity of hereditary colorectal cancer and polyposis susceptibility genes using the Clinical Genome Resource Clinical Validity Framework, Genet Med. 2019 Jul;21(7):1507-1516.
Dominguez-Valentin M, Sampson JR, Seppälä TT, ten Broeke SW, Plazzer JP., Nakken S, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Thomas H, Evans DG , Burn J, Greenblatt M, Hovig E, de Vos tot Nederveen Cappel WH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A, Lopez-Koestner F, Gluck N, Katz L, Heinimann K, Vaccaro CA, Reinhard Bu¨ttner R, Görgens H, Holinski-Feder E, Morak M, Holzapfel S, Hüneburg R, von Knebel Doeberitz M, Loeffler M., Rahner N, Schackert HK, Steinke-Lange V, Schmiegel W, Vangala D, Pylvänäinen K, Renkonen-Sinisalo L, Hopper JL, Win AK, Haile RW, Lindor NM, Gallinger S, Le Marchand L, Newcomb PA, Figueiredo JC, Thibodeau SN, Wadt K, Therkildsen C, Okkels H, Ketabi Z, Moreira L,Sánchez A, Serra-Burriel M, Pineda M, Navarro M, Blanco I, Green K, Lalloo F, Crosbie E, Hill J, Denton OG, Frayling IM., Rødland EA, Vasen H, Mints M, Neffa F, Esperon P, Alvarez K, Kariv R, Rosner G, Pinero TA, Gonzalez ML., Kalfayan P, Tjandra D, Macrae F, Möslein G., Mecklin JP, Nielsen M., Møller P. Cancer risks by gene, age and gender in 6,350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database, Genet Med, 2019, in press. PMID: 31337882
Brnich SE, Abou Tayoun AN, Couch FJ, Cutting GR, Greenblatt MS, Heinen CD, Kanavy DM, Luo X, McNulty SM, Starita LM, Tavtigian SV, Wright MW, Harrison SM, Biesecker LG, Berg JS, Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework, Genome Medicine 2019, in press.
Drost M, Tiersma Y, Glubb D, Kathe S, van Hees S, Ramlal RPE, Thompson BA, Calléja F, Zonneveld JBM, Rasmussen LJ, Greenblatt MS, Lee A, Spurdle AB, Tavtigian SV, de Wind N, A comprehensive, functional analysis-based, procedure for the diagnostic assessment of MSH6 Variants in Lynch Syndrome, Genet Med 2019, in press.
Selected publications:
Hermel DJ, McKinnon WC, Wood ME, Greenblatt MS, Multi-gene Panel Testing for Hereditary Cancer Susceptibility in a Rural Familial Cancer Program, Familial Cancer 2016, Jul in press. PMID: 27401692
Erten MZ, Fernandez LP, Ng HK, McKinnon WC, Heald B, Koliba CJ, Greenblatt MS, Universal versus Targeted Screening for Lynch Syndrome: Comparing Ascertainment and Costs Based on Clinical Experience, Dig Dis Sci, 2016 Oct; 61(10): 2887-95. PMID: 27384051
denDunnen JT, Dagliesh R, Maglott DR, Hart RK, Greenblatt MS, McGowan-Jordan J, Roux A-F, Smith T, Antonarakis SE, Taschner PEM, HGVS Recommendations for the Description of Sequence Variants: 2016 Update, Hum Mutat. 2016 Jun;37(6):564-9. PMID: 26931183