Ph.D., Nutritional Biochemistry and Metabolism, MIT, Cambridge, MA (1977)
M.D., University of Cincinnati College of Medicine, Cincinnati, OH (1972)
B.S. in Zoology, Duke University, Durham, NC (1968)
Research: Effects of long and short chain fatty acids on metabolism and on risks for obesity, type 2 diabetes, and impaired cognitive aging.
Teaching: Nutrient deficiencies, inborn errors of metabolism, obesity, type 2 diabetes, gastroenterology.
Professor emeritus, Departments of Pediatrics and Medicine, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT (2019-present)
Professor, Departments of Pediatrics and Medicine, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT (2004-2019)
The Mary Kay Davignon and James B. Duke Green and Gold Professor of Pediatrics and Medicine, The Robert Larner, M.D. College of Medicine at The University of Vermont (2005-present)
Current:
“Fatty Acid Modulation of Brain Function in Older Adults”
Principal Investigators: J. A. Dumas and C.L. Kien
Agency: 1R01AG085286-01
Period: 12/01/2023 – 11/30/2028
Recent:
"Full-fat Yogurt and Glucose Tolerance"
Principal Investigator: J. Kraft (UVM); C.L. Kien, Co-I
Agency: Dairy Management, Inc.
Period: 11/01/2017 - 12/31/2020
"Mechanisms of Obesity and Its Metabolic Complications in Youth"
Principal Investigator: N. Santoro (Yale Univ.); C.L. Kien, Co-I
Agency: NIH 1 R01 DK114504-01A1
Period: 04/18/2018 - 04/17/2023
"Fatty Acid Effects on Brain Functioning in Normal Aging"
Principal Investigator: J.A. Dumas; C.L. Kien, Co-I
Agency: NIH R56 AG062105
Period: 09/15/2019 - 08/31/2021
• Clinical and Integrative Diabetes and Obesity (CIDO) Study Section (Regular Member) (07/01/2007 - 06/30/2011)
• Biochemistry Test Committee, National Board of Medical Examiners (NBME) (1998-2002)
• Step 1 Test Material Development Committee for Biochemistry United States Medical Licensing Examination (USMLE) (1998-2002)
• Consultant (for Carbohydrates) Term Panel, Life Sciences Research Office (FASEB), (Advisory to FDA) (1996 - 2001)
• Ad Hoc Expert Panel: Review of infant formula nutrient requirements for preterm infants, Life Sciences Research Office (FASEB), (Advisory to FDA)
• Ad Hoc Review of the USMLE Step 1 Pass/Fall Standard (April, 2000)
• Nutrition Study Section (1989 - 1993)
• Special Fellow, Leukemia Society of America, Inc. (1981)
• Future Leaders Award, The Nutrition Foundation, Inc. (1980)
Julie A. Dumas, Janice Y. Bunn, Michael A. LaMantia, Catherine McIsaac, Anna Senft Miller, Olivia Nop, Abigail Testo, Bruno P. Soares, Madeleine M. Mank, Matthew E. Poynter, C. Lawrence Kien. Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake. Aging Brain 3 (2023) https://doi.org/10.1016/j.nbas.2023.100072.
Galuppo B, Umano GR, Li Z, Van Name M, Samuels SL, Kien CL, Cline GW, Wagner DA, Barbieri E, Tricò D, Santoro N. Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity. JAMA Netw Open. 2023 May 1;6(5):e2312530. doi: 10.1001/jamanetworkopen.2023.12530.PMID: 37159195
Galuppo B, Cline G, Van Name M, Shabanova V, Wagner D, Kien CL, Santoro N. Colonic Fermentation and Acetate Production in Youth with and without Obesity. J Nutr. 2021 Nov 2;151(11):3292-3298. doi: 10.1093/jn/nxab2
Parikh R, Bates JHT, Poynter ME, Suratt BT, Parsons PE, Kien CL, Heyland DK, Crain KI, Martin J, Garudathri J, Stapleton RD. Pharmacokinetics of Omega-3 Fatty Acids in Patients with Severe Sepsis Compared with Healthy Volunteers: A Prospective Cohort Study. Clin Nutr. 2020 Mar;39(3):958-965. doi: 10.1016/j.clnu.2019.03.040. Epub 2019 Apr 9. PMID: 31005335
Dumas JA, Bunn JY, Nickerson J, Crain KI, Ebenstein DB, Tarleton EK, Makarewicz J, Poynter ME, Kien CL. Dietary saturated fat and monounsaturated fat have reversible effects on brain function and the secretion of pro-inflammatory cytokines in young women. Metabolism. 2016;65:1582-8, PMID 27621193.
Kien CL, Matthews DE, Poynter ME, Bunn JY, Fukagawa NK, Crain KI, Ebenstein DB, Tarleton EK, Stevens RD, Koves TR, Muoio DM. Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of ß-oxidation. J Lipid Res. 2015;56:1795-807, PMID 26156077
Kien CL, Bunn JY, Fukagawa NK, Anathy V, Matthews DE, Crain KI, Ebenstein DB, Tarleton EK, Pratley RE, Poynter ME. Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of pro-inflammatory cytokines and muscle expression of redox-sensitive genes. J Nutr Biochem. 2015;26:1599-606, PMID 26324406.
Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM. Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans. Am J Clin Nutr. 2014;99:436-45, PMID 24429541.
Kien CL, Bunn JY, Poynter ME, Stevens R, Bain J, Ikayeva O, Fukagawa NK, Champagne CM, Crain KI, Koves TR, Muoio DM. A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults. Diabetes. 2013;62:1054-63, PMID 23238293.
Koves TR, Sparks LM, Kovalik JP, Mosedale M, Arumugam R, DeBalsi KL, Everingham K, Thorne L, Phielix E, Meex RC, Kien CL, Hesselink MKC, Schrauwen P, Muoio DM. PPARgamma coactivator-1alpha contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans. J Lipid Res. 2013;54:522-34, PMID 23175776.
For a complete list of Dr. Kien's publications, please visit Pub Med