Education

B.Sc. in Biochemistry, University of Kent at Canterbury, UK, 1979.
Ph.D. in Biochemistry/Molecular Biology, University of Southampton, UK, 1991.

Research Interests

• Growth factor signaling transduction mechanisms and transcription factors during beta-cell regeneration;
• Islet transcription factors and beta cell mass compensation; and
• Plant bioactive fatty acids in hepatic liver metabolism.

Expertise

Signal transduction pathways and gene regulation in pancreatic islet beta-cell development

Academic Appointments

Research Assistant Professor - Volunteer Pathway, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Larner College of Medicine at The University of Vermont, Burlington, VT, 2013-present.

Research Assistant Professor, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Vermont College of Medicine, Burlington, VT, 2001-2012. 

Publications (Peer Reviewed)

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL. Mechanisms of compensatory beta-cell growth in insulin-resistant rats: Roles of Akt kinase. Diabetes. 2005; 54:2294-2304.

Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, LaRock K, Everill B, Leahy JL, and Jetton TL. Regulation of pancreatic ß-cell regeneration in the normoglycemic 60% partial pancreatectomy mouse. Diabetes. 2006; 55:3289-3298.

Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Jack L. Leahy. Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells. Diabetes. 2007; 56:88-95.

Gupta D, Jetton TL, Mortensen RM, Zhong Duan S, Peshavaria M, Leahy JL. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse PDX-1 promoter. J Biol Chem. 2008; 283:32462-32470.

Lausier J, Diaz WC, Roskens V, LaRock K, Herzer K, Fong CG, Latour M, Peshavaria M, Jetton TL. Vagal control of pancreatic ß-cell proliferation. Am J Physiol Endocrinol Metab. 2010; 299:E786-E793.

Jaworski DM, Sideleva O, Stradecki HM, Langlois GD, Habibovic A, Satish B, Tharp WG, Lausier J, Larock K, Jetton TL, Peshavaria M, Pratley RE.  Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice.  Endocrinology.  2011; 152:1300-1313. 

Gupta D, Leahy AA, Monga N, Peshavaria M, Jetton TL, Leahy JL.  Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and its target genes are downstream effectors of FOXO1 protein in islet beta-cells: Mechanism of beta-cell compensation and failure.  J Biol Chem.  2013; 288:25440-25449.

For a complete list of Dr. Peshavaria's publications, please visit Pub Med.