The main goal of the van der Vliet laboratory is to unravel the molecular mechanisms by which biological and environmental oxidants contribute to lung cell injury, inflammation, and remodeling, as major features of chronic lung diseases such as asthma, COPD and lung cancer.
Nitric oxide synthases and NADPH oxidases in airway biology and pathology; Oxidant mechanisms in inflammation; Chemistry and biology of reactive oxygen and nitrogen species; Environmental oxidants and electrophiles; Lung epithelial cell biology and signaling; Chemical mechanisms of protein oxidation; Proteomic analysis of oxidation and alkylation targets; Antioxidant enzymes and micronutrients.
2/93 - 4/97 Postdoctoral Researcher, Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California, Davis
6/91 - 1/93 Postdoctoral Researcher, Division of Molecular Pharmacology,Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands
1991 Ph.D. Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
1987 B.S./M.S. Subfaculty of Chemistry, Faculty of Mathematics and Physical Sciences, Vrije Universiteit, Amsterdam, The Netherlands
2008 - Present Professor, Department of Pathology, College of Medicine, University of Vermont, Burlington, VT
2002 -2008 Associate Professor, Department of Pathology, College of Medicine, University of Vermont, Burlington, VT
2001 - 2002 Associate Professor in Residence, Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California, Davis
1999 - 2001 Assistant Professor in Residence, Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California, Davis.
1997 - 1999 Assistant Research Biochemist, Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California, Davis
1995 Visiting Scientist, Pharmacology Group, King's College, Chelsea Campus, University of London, U.K.
1999 Joan Oettinger Memorial Award, UC Davis School of Medicine
1996-1998 Parker B. Francis Fellowship Award in Pulmonary Research, Francis Family Foundation
1994-1996 Postdoctoral Fellowship, American Heart Association, California Affiliate
1994 Young Investigator Award, The Oxygen Society
"Identification of tyrosine brominated extracellular proteins in normal and fibrotic lung tissues." Cruz LC, Habibovic A, Dempsey B, Massafera MP, Janssen-Heininger YMW, Lin MJ, Hoffman ET, Weiss DJ, Huang SK, van der Vliet A, Meotti FC. Redox Biology. 2024 Feb 23;71:103102. doi: 10.1016/j.redox.2024.103102. PMID: 38430684
"Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality." Nishimura A, Yoon S, Matsunaga T, Ida T, Jung M, Ogata S, Morita M, Yoshitake J, Unno Y, Barayeu U, Takata T, Takagi H, Motohashi H, van der Vliet A, Akaike T. Redox Biology. 2024 Feb;69:103018. doi: 10.1016/j.redox.2023.103018. Epub 2024 Jan3. PMID: 38199039
"The Concise Guide to PHARMACOLOGY 2023/24: Enzymes." Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Annett S, Boison D, Burns KE, Dessauer C, Gertsch J, Helsby NA, Izzo AA, Ostrom R, Papapetropoulos A, Pyne NJ, Pyne S, Robson T, Seifert R, Stasch JP, Szabo C, van der Stelt M, van der Vliet A, Watts V, Wong SS. British Journal of Pharmacology. 2023 Oct;180 Suppl 2:S289-S373. doi: 10.1111/bph.16181. PMID: 38123154
"Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility." Corteselli EM, Sharafi M, Hondal R, MacPherson M, White S, Lam YW, Gold C, Manuel AM, van der Vliet A, Schneebeli ST, Anathy A, Li J, Janssen-Heininger YMW. Nature Communications. 2023 Jul 28;14(1):4550. doi:10.1038/s41467-023-39664-2. PMID: 37507364; PMCID: PMC10382592. h-index: 449
"Differences in Treatment Response in Bronchial Epithelial Cells from Idiopathic Pulmonary Fibrosis (IPF) Patients: A First Step towards Personalized Medicine?" Veith C, Schneider MA, Mass L, van der Vliet A, van Schooten FJ, Kreuter M, Meister M, Boots AW, Kahn N. Antioxidants (Basel). 2023 Feb 10;12(2):443. doi: 103390/antiox12020443. PMID: 36830000; PMCID: PMC9952618
"Diet-Induced Obesity Worsens Allergen-Induced Type 2/Type 17 Inflammation in Airways by Enhancing DUOX1 Activation." Habibovic A, Hristova M, Morris CR, Lin MJ, Cruz LC, Ather JL, Geizst M, Anathy V, Janssen-Heininger YMW, Poynter ME, Dixon AE, van der Vliet A. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2023 Jan 10. doi: 10.1152/jplung.00331.2022. Epub ahead of print. PMID: 36625485
"Mitoquinone mesylate attenuates pathologic features of lean and obese allergic asthma in mice." Chandrasekaran R, Bruno SR, Mark ZF, Walzer J, Caffry S, Gold C, Kumar A, Chamberlin N, Butzirus IM, Morris CR, Dapahtary N, Aliyeva M, Lam YW, van der Vliet A, Janssen-Heininger Y, Poynter ME, Dixon AE, Anathy V. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2022 Dec 13. doi: 10.1152/ajplung.00249.2022. Epub ahead of print. PMID: 36511516
“Macrophage-intrinsic DUOX1 contributes to type 2
inflammation and mucus metaplasia during allergic airway disease.” Morris CR,
Habibovic A, Dustin CM, Schiffers C, Lin MC, Ather JL, Janssen-Heininger YMW,
Poynter ME, Utermohlen O, Krönke M, van der Vliet A. Mucosal Immunol. 2022
Jun 2. doi: 10.1038/s41385-022-00530-x. Online ahead of print. PMID: 35654836
“Architecture of the NADPH oxidase family of enzymes.” Ogboo BC, Grabovyy UV, Maini A, Scouten S, van der Vliet A, Mattevi A, Heppner
DE. Redox Biol. 2022 Jun;52:102298. doi:
10.1016/j.redox.2022.102298. Epub 2022 Mar 18. PMID: 35334249
“Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications
for Antioxidant Strategies.”
Schiffers C, Reynaert NL, Wouters EFM, van der Vliet A. Antioxidants (Basel). 2021 Nov 11;10(11):1799. doi:
10.3390/antiox10111799. PMID: 34829671 Free PMC article. Review.