Brooke Mossman, Ph.D.

Brooke Mossman, Ph.D.

University of Vermont Distinguished Professor, Professor Emeritus, Department of Pathology & Laboratory Medicine

Contact Information
E-mail: Brooke.Mossman@uvm.edu
Office Location:
Pathology, Given E203, CAMPUS

Expertise

Environmental toxicology, Epithelial cell differentiation, Chemical and Physical Carcinogenesis and Cell Injury, Pulmonary Fibrosis, Oxygen free radicals, Molecular Biology of Antioxidant Enzymes in lung, Cell signaling

Education

1977 Ph.D., University of Vermont, Cell Biology
1970 M.S., University of Vermont, Physiology & Biophysics

Academic Appointments

2013-present Professor Emeritus, Department of Pathology & Laboratory Medicine
1995 - 2013 Director, Environmental Pathology Program, University of Vermont
1995 - 1998 Program Leader, Cell Signaling and Growth Control Research Program, Vermont Cancer Center
1992 - 2013 Professor, Department of Pathology, University of Vermont
1989 - 2012Adjunct Faculty Member, In Vitro Cell Biology and Biotechnology Program, State University of New York, Plattsburgh, NY
1984 - 1992 Associate Professor, Department of Pathology, University of Vermont
1984 - 1988 Chair, Cell and Molecular Biology Program, University of Vermont
1980 - 1983 Assistant Professor, Department of Pathology, University of Vermont
1978 - 1980 Research Assistant Professor, Department of Pathology, University of Vermont
1975 - 1977 Research Associate, Department of Pathology, University of Vermont
1973 - 1974 Research Assistant, Department of Pathology, University of Vermont
1970 - 1973 Research Assistant, Institute of Environmental Medicine, New York University, Sterling Forest, NY
1968 - 1970 Research Assistant, Department of Obstetrics & Gynecology, University of Vermont

Awards and Honors

2011   University Distinguished Professor Award, University of Vermont
2010   University of Vermont College of Medicine Medical Alumni Association Graduate Alumni Award
2008   Wagner Award, International Mesothelioma Interest Group Meeting, Amsterdam, NL, for Historic Contributions to Mesothelioma Research
2007   American Thoracic Society Career Achievement Recognition Award for Scientific Accomplishments
2004   Alumni Achievement Award, University of Vermont College of Medicine
1981-1982   University of Vermont Medical Scholar Award for "outstanding and sustained research and scholarly contributions to both the academic discipline and the life of the University of Vermont"

Publications

"Mechanisms and shapes of casual exposure-response functions for asbestos in mesothelioma and lung cancers." Cox LA, Bogen KT, Conolly R, Graham U, Moolgavkar S, Oberdörster G, Roggli VL, Turci F, Mossman B,. Environmental Research. 2023 Aug 1;230:115607. doi: 10.1016/j.envres.2023.115607. Epub Mar 23. PMID: 36965793. h-index: 167 

 

“Letter to the Editor: Fletcher NM, Harper AK, Memaj I, Fan R, Morris RT, Saed GM. Molecular Basis Supporting the Association of Talcum Powder Use with Increased Risk of Ovarian Cancer. Reprod Sci. 2019;26(12):1603-12. DOI: 10.1177/1933719119831773.” Mossman BT. Reprod Sci. 2020 Oct;27(10):1834-1835. doi: 10.1007/s43032-020-00265-9. Epub 2020 Aug 19. PMID: 32813197 No abstract available.

“Mechanistic in vitro studies: What they have told us about carcinogenic properties of elongated mineral particles (EMPs).” Mossman BT. Toxicol Appl Pharmacol. 2018 Dec 15;361:62-67. doi: 10.1016/j.taap.2018.07.018. Epub 2018 Jul 17. Review. PMID: 30030095


“Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells.” 
Perkins TN, Peeters PM, Albrecht C, Schins RPF, Dentener MA, Mossman BT, Wouters EFM, Reynaert NL. Toxicol Appl Pharmacol. 2018 Jun 1;348:43-53. doi: 10.1016/j.taap.2018.04.011. Epub 2018 Apr 17. PMID: 29673857

“The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases.” Sayan M, Mossman BT. Part Fibre Toxicol. 2016 Sep 20;13(1):51. doi: 10.1186/s12989-016-0162-4. Review. PMID: 27650313 Free PMC Article