Yvonne Janssen-Heininger, Ph.D.

Yvonne Janssen-Heininger, Ph.D.

Professor, Department of Pathology & Laboratory Medicine
UVM Cancer Center Member

Contact Information
E-mail: Yvonne.Janssen@uvm.edu
Office Location:
Health Science Research Facility 216A

Expertise

Protein-thiol-redox based Signaling, S-glutathionylation, Airway Epithelial Biology, Asthma, Pulmonary Fibrosis, Transcription Factors: Nuclear Factor Kappa B, death receptors: Fas, Epithelial to Mesenchymal Transition, c-Jun-N-terminal kinase, Fibrosis

Academic Interests

To provide an exciting research environment and extensive mentoring to all laboratory members to enable each of them to be maximally successful in the arena of biomedical sciences in diverse capacities.

Research Interests

To unravel the molecular basis of diverse pulmonary diseases by emphasizing the biology of epithelial cells and redox-dependent processes.

Postdoctoral Training

10/1/93 - 6/30/96 Postdoctoral Associate, University of Vermont, Department of Pathology, Burlington, VT

Education

1993  Ph.D.: Maastricht University, The Netherlands In alliance with: Maastricht University Medical Center, Di-One Institute
1988  BA/MS - University of Limburg, Maastricht, The Netherlands. Major: Biological Health Sciences, Faculty of Health Sciences

Academic Appointments

2017- 2021 Vice-Chair for Research, Department of Pathology & Laboratory Medicine,  The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT
2008 - Present Professor, University of Vermont, Department of Pathology, Burlington, VT
1999 - Present Adjunct Professor, Department of Pulmonology University of Maastricht, Maastricht, The Netherlands
2002 - 2008 Associate Professor, University of Vermont, Department of Pathology, Burlington, VT
1997 - 2002 Assistant Professor, University of Vermont, Department of Pathology, Burlington, VT
1996 - 1997 Research Assistant Professor, University of Vermont, Department of Pathology, Burlington, VT

Awards and Honors

2022 University of Vermont Distinguished Professor
2021 Dean’s Research Laureate Award, Larner College of Medicine, University of Vermont
2020 Fellow of the Society for Redox Biology and Medicine
2014–2016 Elected Chair, Lung Injury Repair and Remodeling Study Section, National Institutes of Health
2010-2016  Member, National Institutes of Health, Lung Injury, Repair and Remodeling Study Section
2010  "J. Walter Juckett Scholar Award", Lake Champlain Cancer Research Organization
2002-2005  Member, National Institutes of Health, Lung Biology and Pathology Study Section
1996-1997  "Senator Proctor Research Award", American Lung Association of Vermont
1996  "JAAP Swierenga Award", Dutch College of Chest Physicians, The Netherlands
1995-1998  "Parker B. Francis Fellowship in Pulmonary Research"
1994  "Thesis Award 1992-1993" Nutrition Toxicology and Environmental Research Institute, Maastricht, The Netherlands

Publications

"Diet-Induced Obesity Worsens Allergen-Induced Type 2/Type 17 Inflammation in Airways by Enhancing DUOX1 Activation." Habibovic A, Hristova M, Morris CR, Lin MJ, Cruz LC, Ather JL, Geizst M, Anathy V, Janssen-Heininger YMW, Poynter ME, Dixon AE, van der Vliet A. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2023 Jan 10. doi: 10.1152/ajlpung.00331.2022. Epub ahead of print. PMID: PMC9827435

"Mitoquinone mesylate attenuates pathologic features of lean and obese allergic asthma in mice." Chandrasekaran R, Bruno SR, Mark ZF, Walzer J, Caffry S, Gold C, Kumar A, Chamberlin N, Butzirus IM, Morris CR, Dapahtary N, Aliyeva M, Lam YW, van der Vliet A, Janssen-Heininger Y, Poynter ME, Dixon AE, Anathy V. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2022 Dec 13. doi: 10.1152/ajplung.00249.2022. Epub ahead of print. PMID: 3651516 

"S Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis." Corteselli E, Aboushousha R, Janssen-Heininger Y. Antioxidants (Basel). 2022 Sep 10;11(9):1789. doi: 10.3390/antiox11091789. PMID: 36139863

“Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo.” Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson NG, Milne GL, Nyström T, Poulsen HE, Radi R, Van Remmen H, Schumacker PT, Thornalley PJ, Toyokuni S, Winterbourn CC, Yin H, Halliwell B. Nat Metab. 2022 Jun;4(6):651-662. doi: 10.1038/s42255-022-00591-z. Epub 2022 Jun 27. PMID: 35760871 Review.

“Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.” Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Thorax. 2022 Jul;77(7):669-678. doi: 10.1136/thoraxjnl-2021-216882. Epub 2021 Aug 16. PMID: 34400514

“Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease.” Morris CR, Habibovic A, Dustin CM, Schiffers C, Lin MC, Ather JL, Janssen-Heininger YMW, Poynter ME, Utermohlen O, Krönke M, van der Vliet A. Mucosal Immunol. 2022 Jun 2. doi: 10.1038/s41385-022-00530-x. Online ahead of print. PMID: 35654836

 

 “Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2.” van de Wetering C, Manuel AM, Sharafi M, Aboushousha R, Qian X, Erickson C, MacPherson M, Chan G, Adcock IM, ZounematKermani N, Schleich F, Louis R, Bohrnsen E, D'Alessandro A, Wouters EF, Reynaert NL, Li J, Wolf CR, Henderson CJ, Lundblad LKA, Poynter ME, Dixon AE, Irvin CG, van der Vliet A, van der Velden JL, Janssen-Heininger YM. Redox Biol. 2021 Nov;47:102160. doi: 10.1016/j.redox.2021.102160. Epub 2021 Oct 3. PMID: 34624602 Free PMC article.

“Oxidation of peroxiredoxin-4 induces oligomerization and promotes interaction with proteins governing protein folding and endoplasmic reticulum stress.” Elko EA, Manuel AM, White S, Zito E, van der Vliet A, Anathy V, Janssen-Heininger YMW. J Biol Chem. 2021 Jan-Jun;296:100665. doi: 10.1016/j.jbc.2021.100665. Epub 2021 Apr 23. PMID: 33895140 Free PMC article.

“Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.” Schiffers C, Lundblad LKA, Hristova M, Habibovic A, Dustin CM, Daphtary N, Aliyeva M, Seward DJ, Janssen-Heininger YMW, Wouters EFM, Reynaert NL, van der Vliet A. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L144-L158. doi: 10.1152/ajplung.00021.221. PMID: 33951398

“Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?” van de Wetering C, Elko E, Berg M, Schiffers CHJ, Stylianidis V, van den Berge M, Nawijn MC, Wouters EFM, Janssen-Heininger YMW, Reynaert NL. Redox Biol. 2021 Jul;43:101995. doi: 10.1016/j.redox.2021.101995. PMID: 33979767 Free PMC article.