To improve interdisciplinary opportunities for graduate education in the biomedical sciences.
To exploit perturbations in redox signaling to develop new therapeutic approaches to treat malignant mesothelioma and other solid tumor types.
1979-1983 University of Virginia Postdoc Molecular Genetics
1979 University of Vermont Ph.D. Medical Microbiology
1976 University of Vermont M.S Cell Biology
1971 College of Holy Cross B.A. English Literature
2014-Present Professor Emeritus, Department of Pathology and Laboratory Medicine
2010-2012 Interim Director, Basic Science Research, Vermont Cancer Center
2002-2006 Leader, Cell Signaling and Growth Control Program, Vermont Cancer Center
2002-2006 Director, DNA Analysis and Flow Cytometry Cores, Vermont Cancer Center
1999-2014 Professor, Pathology, University of Vermont College of Medicine
1999-2014 Professor, Microbiology and Molecular Genetics, University of Vermont College of Medicine
1992-1999 Associate Professor, Pathology, University of Vermont College of Medicine
1992-1999 Associate Professor, Microbiology and Molecular Genetics, University of Vermont College of Medicine
1986-1992 Assistant Professor, Pathology, University of Vermont College of Medicine
1983-1986 Research Assistant Professor, Pathology, University of Vermont College of Medicine
2002 Visiting Research Professor, European Institute of Oncology, Milan Italy
2001-2002 Senior Research Service Award, NIHGMS
1994-1998 American Cancer Society Personnel A Committee
1993-1998 American Cancer Society Faculty Research Award
1997 Foundation for the Promotion of Cancer Research, Senior Visiting Professor, National Cancer Center Research Institute, Tokyo, Japan
1994-1996 Molecular Biology Study Section, NIH
1993-1994 J. Walter Juckett Scholar, Lake Champlain Cancer Research Organization
1986 Visiting Scientist Fellowship, MBCRR, Harvard University
1979-1983 National Research Service Award, National Institutes of Health
1982 President’s and Board Visitors’ Research Prize, University of Virginia
1979 Postdoctoral Research Fellowship, American Cancer Society (declined)
1978 President’s Fellowship, American Society for Microbiology
“Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.” Elko EA, Cunniff B, Seward DJ, Chia SB, Aboushousha R, van de Wetering C, van der Velden J, Manuel A, Shukla A, Heintz NH, Anathy V, van der Vliet A, Janssen-Heininger YMW. Antioxid Redox Signal. 2019 Nov 10;31(14):1070-1091. doi: 10.1089/ars.2019.7752. Epub 2019 Apr 5. PMID: 30799628 Review.
“AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion.” Cunniff B, McKenzie AJ, Heintz NH, Howe AK. Mol Biol Cell. 2016 Sep 1;27(17):2662-74. doi: 10.1091/mbc.E16-05-0286. Epub 2016 Jul 6. PMID: 27385336 Free PMC Article
“Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.” Cunniff B, Newick K, Nelson KJ, Wozniak AN, Beuschel S, Leavitt B, Bhave A, Butnor K, Koenig A, Chouchani ET, James AM, Haynes AC, Lowther WT, Murphy MP, Shukla A, Heintz NH. PLoS One. 2015 May 26;10(5):e0127310. doi: 10.1371/journal.pone.0127310. eCollection 2015. PMID: 26011724 Free PMC Article
“Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells.” Cunniff B, Wozniak AN, Sweeney P, DeCosta K, Heintz NH. Redox Biol. 2014;3:79-87. doi: 10.1016/j.redox.2014.11.003. Epub 2014 Nov 18. PMID: 25462069 Free PMC Article
“Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation.” Thompson JK, Westbom CM, MacPherson MB, Mossman BT, Heintz NH, Spiess P, Shukla A. Part Fibre Toxicol. 2014 May 20;11:24. doi: 10.1186/1743-8977-11-24. PMID: 24885895 Free PMC Article