Research Interests

Endoplasmic Reticulum (ER) stress and Protein Disulfide Isomerases in Asthma.
Unfolded Protein Response in respiratory virus infection.
Redox regulation of inflammatory response and airway remodeling in asthma.
Redox regulation of fibroblast proliferation in pulmonary fibrosis

Postdoctoral Training

2004-2007 Postdoctoral Associate, Department of Pathology, University of Vermont College of Medicine

Education

1999-2004 PhD, Biological Sciences, Madurai Kamaraj University, Madurai, India
1994-1996 MSc, Biotechnology, University of Mysore, Mysore, India
1990-1994 BSc, Biochemistry, Botany & Zoology, University of Mysore, Mysore, India

Academic Appointments

2019 - present Associate Professor with tenure, Depart of Pathology and Laboratory Medicine, Larner College of Medicine University of Vermont
2015-2019 Assistant Professor (Tenure Track), Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine
2013-2015 Assistant Professor (Research Track), Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine
2007-2013 Research Associate, Department of Pathology, University of Vermont College of Medicine

Awards and Honors

2015 UVM nominee for the Searle scholar award’s nationwide competition
2014 Asthma and Allergy Foundation of America-Sheldon C. Siegel Award
2014 American Thoracic Society Abstract Scholarship ATS-2014, San Diego
2012 American Thoracic Society Jo Rae Wright Award
2010 American Thoracic Society Travel Award ATS-2010, New Orleans
2000-2002 Senior Research Fellow, Scholarship Award and stipend from Council of Scientific and Industrial Research, India
1997-2000 Junior Research Fellow, Scholarship Award and stipend from Department of Biotechnology, India
1996-1997 Research Assistant, Scholarship Award including Salary Support from Department of Biotechnology, India

Publications

"Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway." Chandrasekaran R, Morris CR, Butzirus IM, Mark ZF, Kumar A, Souza De Lima D, Daphtary N, Aliyeva M, Poynter ME, Anathy V, Dixon AE. Frontiers in Pharmacology. 2023 Aug 23;14:1248873. doi: 10.3389/fphar.2023.1248873. eCollection 2023. PMID: 37680710

"Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility." Corteselli EM, Sharafi M, Hondal R, MacPherson M, White S, Lam YW, Gold C, Manuel AM, van der Vliet A, Schneebeli ST, Anathy A, Li J, Janssen-Heininger YMW. Nature Communications. 2023 Jul 28;14(1):4550. doi:10.1038/s41467-023-39664-2. PMID: 37507364; PMCID: PMC10382592. h-index: 449

"Deletion of Miro1 in airway club cells potentiates allergic asthma phenotypes." Bruno S, Lamberty A, McCoy M, Mark Z, Daphtary N, Aliyeva M, Butnor K, Poynter ME, Anathy V, & Cunniff B. Frontiers in Allergy. 2023 4, 1187945. https://doi.org/10.3389/falgy.2023.1187945. H-Index: 4

"Diet-Induced Obesity Worsens Allergen-Induced Type 2/Type 17 Inflammation in Airways by Enhancing DUOX1 Activation." Habibovic A, Hristova M, Morris CR, Lin MJ, Cruz LC, Ather JL, Geizst M, Anathy V, Janssen-Heininger YMW, Poynter ME, Dixon AE, van der Vliet A. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2023 Jan 10. doi: 10.1152/ajplung.00331.2022. Epub ahead of print. PMID: 3662548

"Mitoquinone mesylate attenuates pathologic features of lean and obese allergic asthma in mice." Chandrasekaran R, Bruno SR, Mark ZF, Walzer J, Caffry S, Gold C, Kumar A, Chamberlin N, Butzirus IM, Morris CR, Dapahtary N, Aliyeva M, Lam YW, van der Vliet A, Janssen-Heininger Y, Poynter ME, Dixon AE, Anathy V. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2022 Dec 13. doi: 10.1152/ajplung.00249.2022. Epub ahead of print. PMID: 36511516

Editorial: "Oxidative stress related to cellular metabolism in lung health and diseases." Arunachalam K, Anand K, Palanisamy S, Anathy V. Frontiers in Pharmacology. 2022 Nov 3;13:1015423. doi: 10.3389/fphar.2022. 1015423. PMID: 36408268; PMCID: PMC9670798

“Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.” Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Thorax. 2022 Jul;77(7):669-678. doi: 10.1136/thoraxjnl-2021-216882. Epub 2021 Aug 16. PMID: 34400514

“Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung.” Chamberlain N, Ruban M, Mark ZF, Bruno SR, Kumar A, Chandrasekaran R, Souza De Lima D, Antos D, Nakada EM, Alcorn JF, Anathy V. Int J Mol Sci. 2022 Jan 19;23(3):1078. doi: 10.3390/ijms23031078. PMID: 35162999 Free PMC article.

“DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen.” Bruno SR, Kumar A, Mark ZF, Chandrasekaran R, Nakada E, Chamberlain N, Mihavics B, Walzer J, Cahoon J, Dixon AE, Cunniff B, Anathy V. Int J Mol Sci. 2021 Oct 15;22(20):11125. doi: 10.3390/ijms222011125. PMID: 34681784 Free PMC article.

“Oxidation of peroxiredoxin-4 induces oligomerization and promotes interaction with proteins governing protein folding and endoplasmic reticulum stress.” Elko EA, Manuel AM, White S, Zito E, van der Vliet A, Anathy V, Janssen-Heininger YMW.J Biol Chem. 2021 Jan-Jun;296:100665. doi: 10.1016/j.jbc.2021.100665. Epub 2021 Apr 23. PMID: 33895140 Free PMC article.