Masayo Koide, Ph.D.

Masayo Koide, Ph.D.

Research Assistant Professor
Department of Pharmacology

Contact Information
E-mail: Masayo.Koide@uvm.edu
Office Location:
89 Beaumont Ave, Given B329, Burlington, VT 05405

Research Interests

Cardiovascular pharmacology and physiology; the contractile mechanism of cerebral arteries (ion channels and intracellular signaling), cerebral vasospasm following subarachnoid hemorrhage.

Education

1998  B.S., University of Shizuoka, School of Pharmaceutical Science, Shizuoka, Japan

2000  M.S., Pharmacology, University of Shizuoka, Graduate School of Pharmaceutical Science, Shizuoka, Japan

2005  Ph.D., Pharmacology, University of Shizuoka, Graduate School of Pharmaceutical Science, Shizuoka, Japan

2005  Ph.D., Medicine, University of Hamamatsu School of Medicine, Hamamatsu, Japan

Academic Appointments

2015 to present  Research Assistant Professor, Department of Pharmacology, University of Vermont

2010 - 2015  Research Associate, Department of Pharmacology, University of Vermont

2005 - 2010  Postdoctoral Associate, Department of Pharmacology, University of Vermont

Research Grants

07/01/2014 - 06/30/2018  American Heart Association, National Center, Scientist Development Grant (14SDG20150027).  Mechanisms of EGF receptor activation leading to decreasing cerebral blood flow after subarachnoid hemorrhage.  Role:  PI

Awards and Honors

2012  Award Finalist of Next Big Idea, 11th International Conference on Neurovascular Events after Subarachnoid Hemorrhage. "Subarachnoid blood converts neutrally-evoked vasodilation to vasoconstriction in rat brain cortex"

2012  Award Finalist of Young Investigator, 11th International Conference on Neurovascular Events after Subarachnoid Hemorrhage. "Subarachnoid blood converts neutrally-evoked vasodilation to vasoconstriction in rat brain cortex"

2011, April 25  Invited Speaker, "Microvascular constriction and Ca2+ signaling after subarachnoid hemorrhage", University of Shizuoka, Shziuoka, Japan

2002  The 75th Annual Meeting Best Presentation Prize, The Japanese Pharmacological Society

Publications (Peer Reviewed)

For a complete list of Masayo Koide's publications, please visit PubMed.

2017  Wang F, Koide M, Wellman GC.  Nifedipine Inhibition of High-Voltage Activated Calcium Channel Currents in Cerebral Artery Myocytes Is Influenced by Extracellular Divalent Cations.  Front Physiol. 2017 Apr 7;  8:  210.  doi:  10.3389/fphys.2017.00210. eCollection 2017.  PMID:  28439241;  PMCID:  PMC5383720

2017  Longden TA, Dabertrand F, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT.  Capillary K+ sensing initiates retrograde hyperpolarization to increase local cerebral blood flow.  Nat Neurosci.  2017 May;  20(5):  717-726.  doi:  10.1038/nn.4533.  PMID:  28319610, PMCID:  PMC5404963

2017  Balbi M, Koide M, Wellman CG, Plesnila N.  Inversion of neurovascular coupling after subarchnoid hemorrhage in vivo.  J Cereb Blood Flow Metab.  2017 Nov;  37(11):  3625-3634.  doi:  10.1177/0271678X16686595.  PMID:  28112024, PMCID:  PMC5669344

2017  Balbi M, Koide M, Schwarzmaier SM, Wellman GC, Plesnila N.  Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo.  J Cereb Blood Flow Metab.  2017 Jan;  37(1):  178-187.  doi:  10.1177/0271678X15621253.  PMID:  26676226

2016  Pappas AC, Koide M, Wellman GC.  Purinergic signaling triggers endfoot high-amplitude Ca2+ signals and causes inversion of neurovascular coupling after subarachnoid hemorrhage.  J Cereb Blood Flow Metab.  2016 Nov; 36(11):  1901-1912.  doi:  10.1177/0271678X16650911.  PMID:  27207166, PMCID:  PMC5094310
 

2015  Pappas AC, Koide M, Wellman GC.  Astrocyte Ca2+ Signaling Drives Inversion of Neurovascular Coupling after Subarachnoid Hemorrhage.  J Neurosci.  2015 Sep 30;  35(39):  13375-13384.  doi:  10.1523/JNEUROSCI.1551-15.2015.  PMID:  26424885, PMCID:  4588610

2015  Koide M, Wellman GC.  Activation of TRPV4 channels does not mediate inversion of neurovascular coupling after SAH.  Acta Neurochir Suppl.  doi:  10.1007/978-3-319-04981-6_19.  PMID:  25366609, PMCID:  PMC4465266

2015  Koide M, Wellman GC.  SAH-induced MMP activation and KV current suppression is mediated via ROS-dependent and ROS-independent mechanisms.  Acta Neurochir Suppl.  doi:  10.1007/978-3-319-0498-5_15.  PMID:  25366605, PMCID:  PMC4465535

2014  Koide M, Syed AU, Brass KM, May V, Wellman GC.  Pituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large conductance Ca2+ activated K+ (BK) and ATP-sensitive K+ (KATP) channels.  Journal of Molecular Neuroscience.  doi:  10.1007/s12031-014-0301-z.  PMID:  24744252, PMCID:  PMC3610342

2013  Koide M, Sukhotinsky I, Ayata C, Wellman GC.  Subarachnoid hemorrhage, spreading depolarizations and impaired neurovascular coupling.  Stroke Res and Treatment.  doi:  10.115/2013/819340.  PMID:  23577279, PMCID:  PMC3610342

2013  Koide M, Wellman GC.  SAH-induced suppression of voltage-gated K+ (KV) channel currents in parenchymal arteriolar myocytes involves activation of the HB-EGF/EGFR pathway.  Acta Neurochir Suppl.  doi: 10.1007/978-3-7091-1192-5_34.  PMID:  22890666, PMCID:  PMC3703825

2013  Koide M, Bonev AD, Nelson MT, Wellman GC.  Subarachnoid blood converts neutrally evoked vasodilation to vasoconstriction in rat brain cortex.  Acta Neurochir Suppl.  doi:  10.1007/978-3-7091-5_32.  PMID:  22890664, PMCID:  PMC3684063

2013  Wellman GC, Koide M.  Impact of Subarachnoid Hemorrhage on Parenchymal Arteriolar Function.  Acta Neurochir Suppl.  doi:  10.1007/978-3-7091-1192-5_33.  PMID:  22890665, PMCID:  PMC3703753