Website

Lab

Education

1973 B.S. (Biology) - Union College, Schenectady, N.Y.

1982 Ph.D. (Physiology & Biophysics) - University of Vermont, College of Medicine

Awards and Honors

2014 Distinguished Investigator Award, Cardiovascular Institute of Vermont

1992 - 1996 Member of the Experimental Cardiovascular Sciences study section (Division of Research Grants, NIH)

1990 - 1995 Established Investigator of the American Heart Association

1986 - 1989 PHS NIH New Investigator Award

1983 - 1985 PHS NRSA Postdoctoral Fellowship

1973 Cum Laude graduate, Union College

1969 - 1973 Clark Foundation Scholarship (full undergraduate tuition and fees)

1969 - 1973 New York State Regents Scholarship

1968 National Science Foundation Summer Fellowship, Brown University

Publications

For a complete list of Joseph E. Brayden's publications, please visit PubMed

2019 Syed AU, Koide M, Brayden JE, Wellman GC.  Tonic regulation of middle meningeal artery diameter by ATP-sensitive potassium channels.  J Cereb Blood Flow Metab.  2019 Apr; 39(4): 670-679.  doi:  10.1177/0271678X17749392.  PMID:  29260608, PMCID:  PMC6446425

2017 Longden TA, Dabertrand F, Koide M, Gonzales Al, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT.  Capillary K⁺-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow.  Nat Neurosci.  2017 May; 20(5):  717-726.  doi:  10.1038/nn.4533.  PMID:  28319610, PMCID:  PMC5404963

2017 Li Y, Brayden JE.  Rho kinase activity governs arteriolar myogenic depolarization.  J Cereb Blood Flow Metab. 2017 Jan; 37(1):  140-152.  doi:  10.1177/0271678X15621069.  PMID: 26661251, PMCID:  5363734

2015 Moon TM, Tykocki NR, Sheehe JL, Osborne BW, Tegge W, Brayden JE, Dostmann WR.  Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase 1a Chem Biol. 2015 Dec 17; 22(12): 1653-1661. doi:  10.1016/j.chembiol.2015.11.005.  PMID:  26687482, PMCID:  PMC4703045

2015  Early S, Brayden JE.  Transient receptor potential channels in the vasculature.  Physiol Rev.  doi:  10.1152/physrev.00026.2014.  PMID:  25834234

2015  Dabertrand F, Kroigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.  Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in genetic model of small vessel disease.  Proc Natl Acad Sci USA.  doi:  10.1073/pnas.1420765112.  PMID:  25646445, PMCID:  PMC4343103

2014  Li Y, Baylie RL, Tavares MJ, Brayden JE.  TRPM4 channels couple purinergic receptor mechanoactivation and myogenic tone development in cerebral parenchymal arterioles.  J Cereb Blood Flow Metab.  2014 Aug 6.  doi:  10.1038/jbfm.2014.139.  PMID:  24099756, PMCID:  PMC4269733

2014  Cipolla MJ, Chan SL, Sweet J, Tavares MJ, Gokina N, Brayden JE.  Postischemic reperfusion casues smooth muscle calcium sensitization and vasoconstriction of parenchymal arterioles.  Stroke.  2014 Aug;  45(8):  2425-2430.  doi:  10.1161/STROKEAHA.114.005888.  PMID:  24968928, PMCID:  PMC4144269

2014  Cipolla MJ, Sweet J, Chan SL, Tavares MJ, Gokina N, Brayden JE.  Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arterioles:  role of ion channels and calcium sensitivity.  J Appl Physiol (1985).  2014 Jul 1;  117(1):  53-59.  doi:  10.1152/japplyphysiol.00253.2014.  PMID:  24790017, PMCID:  PMC4101583

2014  Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.  Local control of RPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.  J Gen Physiol.  2014 May:  143(5):  559-575.  doi:  10.1085/jgp.201311050.  PMID:  24778429, PMCID:  PMC4003184